Walker then starred in the crime thriller Running Scared and Walt Disney Pictures' Eight Below, both released in 2006. Eight Below garnered critical-acclaim and opened in first place at the box office, grossing over US$20 million during its first weekend.^[18] During the filming of Running Scared, directorWayne Kramer stated that "[Walker] is that guy on some level"^[19] when comparing Walker with his character in the movie, Joey Gazelle. Kramer continued on to say that he "loved working with [Walker] because as a director he's completely supportive of my vision of what the film is. And even better, he's completely game for it."^[19]

Walker starred in the independent film The Lazarus Project, which was released on DVD on October 21, 2008. He subsequently returned to The Fast and the Furious franchise, reprising his role in Fast & Furious, which was released on April 3, 2009.^[20] Walker then appeared in the crimedrama Takers, which began filming in early September 2008 and was released in August 2010.^[21]

The Coty Prestige fragrance brand Davidoff Cool Water for Men announced in January 2011 that Walker was going to be the new face of the brand as of July 2011.^[22] He reprised his role in the fifth installment of The Fast and the Furious series, Fast Five (2011), and again in Fast & Furious 6 (2013). For this film, he won the 2014 MTV Movie Award as best on-screen duo, with Vin Diesel. He was part of an ensemble cast in Wayne Kramer's Pawn Shop Chronicles (2013), which was Walker's last film released before his death.

Shortly after his death, the Hurricane Katrina based film Hours, which he had completed earlier in 2013, was released on December 13, 2013. He had also completed the action film Brick Mansions, a remake of the French film District 13, which was released in April 2014. At the time of his death, Walker had been filming Furious 7, which was slated for release in July 2014. The film was completed by using his brothers Caleb and Cody as his body doubles/stand-ins, and CGI, and was released in April 2015.^[23][24][25] Walker was also set to play Agent 47 in the video game adaptation Hitman: Agent 47, but died before production began.^[26]